Gleason Grading Courses

Course Authors



Thomas M. Wheeler, MD, FCAP
Baylor College of Medicine

 


George J. Netto, MD, FCAP
Penn Medicine
 


Gladell Paner, MD, FCAP
University of Chicago

The Gleason grading system is the most widely used grading system to characterize cancerous prostate cells according to two current grading protocols:

  • The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma
  • The 2019 Genitourinary Pathology Society (GUPS) White Paper on Contemporary Grading of Prostate Cancer

Gleason grading is prone to subjectivity that leads to inter-observer variability. More accurate Gleason grading, combined with standardized prostate pathology reporting, will lead to accurate diagnosis and will positively impact patient outcomes. The CAP offers three genitourinary pathology courses to help academic and community pathologists focusing on prostate disease screening, diagnosing, monitoring, and reporting. Whether these are current responsibilities now or in the future, these courses will keep you abreast of current scientific knowledge and best practices.

 

Assigning a Gleason Score

This course explains how to assign a Gleason score to challenging tumors such as small foci, multifocal tumors, and multiple adenocarcinoma variants and other carcinomas. This activity will focus on how to grade and report these tumors effectively in the context of needle biopsy and radical prostatectomies, while avoiding undergrading that can lead to incorrect treatment.

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The Effects of Prostate Cancer Treatment

Different treatments can have profound effects on benign tissue and cancer morphology. This course focuses on the effects that radiation, androgen ablation, and other therapies have on prostate specimens. It also explains how the effects of treatments impact Gleason score assignments.

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The Building Blocks of Gleason Scoring

Proper Gleason scoring considers the salient differences between classical and ISUP-modified Gleason scoring. This course covers the clinical significance of the Gleason score including its use in nomograms to determine subsequent management.

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Other Genitourinary Courses

Difficult Diagnoses in Genitourinary Pathology Mimickers

Course Authors



Giovanna A. Giannico, MD, FCAP
University of California - Irvine
 


Sean R. Williamson, MD, FCAP
Cleveland Clinic

 

This course addresses challenging scenarios and contemporary differential diagnosis for a broad array of genitourinary specimens. Using a case presentation with an organ-based approach, it addresses evolving concepts in old and emerging entities, diagnostic pitfalls, and controversies in numerous genitourinary cancer subtypes.

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Variants, Divergence, and Molecular Findings in Urothelial Carcinoma

Course Authors



Hikmat A. Al-Ahmadie, MD
Memorial Sloan-Kettering Cancer Center


Lara R. Harik, MD, FCAP
Emory University

 

Recognizing and consistently reporting the morphologic features of clinically significant variant/divergent histology in the urothelial tract is important. The course covers the differential diagnosis including the preneoplastic lesions and mimickers to ensure accurate recognition and the role of molecular advances in the diagnosis, classification, and management of urothelial carcinoma, including when and how to fully integrate such advances in routine diagnostic practice.

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Updates in Adult Renal Neoplasia

Course Author



Michelle S. Hirsch, MD, PhD, FCAP
Brigham and Women's Hospital

 

This course covers recent updates in the 5th edition of the WHO classification of adult renal epithelial tumors and discusses some emerging entities, with a goal to apply morphologic features to form a differential diagnosis for adult renal epithelial tumor subtypes and how to confirm such diagnoses using ancillary studies.

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Practical Approach to the Classification and Staging of Invasive Urothelial Carcinoma

Course Author



Donna E. Hansel, MD, PhD, FCAP
MD Anderson Cancer Center

 

Focusing on invasive urothelial carcinomas and other major urinary tract carcinomas affecting the bladder, prostate, and upper urinary tract, this course highlights key diagnostic features associated with squamous cell carcinoma and adenocarcinoma in the urinary tract.

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For online CME courses on other topics to help you succeed in your career, you can search the CAP's online course catalog.