Pricing: Member: $70.00 NonMember: $91.00 Junior Member: $15.00

Intended Audience
This activity is appropriate for all pathologists and trainees who would like to improve their understanding in utilizing advanced molecular diagnostic tools in pathology diagnoses.

Description
Ten years after the surge of next-generation sequencing (NGS) adoption into clinical laboratories, the role and applications of molecular and genomic analysis in the diagnosis and management of solid tumors and hematologic malignancies continue to expand. The possibilities for broad genomic and transcriptomic surveillance have recently exploded, with the prospect of routine genome-wide DNA methylation analysis looming on the horizon. There’s no need to feel intimidated. In this activity, you will learn about emerging molecular diagnostic techniques that are revolutionizing tumor classification and impacting management decisions in oncology. You will also be presented with real-life case examples to illustrate scenarios in which NGS-based minimal residual disease monitoring, gene expression profiling classification, DNA methylation-based tumor classification, and integrated genomic and transcriptomic analyses play a central role in the diagnostic workup, classification, and risk stratification of tumors.

This activity was originally presented at CAP24 as Applying Advanced Molecular Technology to Pathology Diagnoses: New Tools and New Classifications!.

Objectives
After completing this activity, you should be able to:

1. Identify scenarios in which emerging advanced molecular diagnostic tools could refine disease classification or impact therapeutic decision-making.
2. Describe the advantages and disadvantages of emerging molecular diagnostic techniques.
3. Recognize and communicate the pertinent information provided by molecular ancillary studies.

Authors/Faculty
Larissa V. Furtado, MD, FCAP
Yen-Chun Liu, MD, PhD, FCAP

CME Information
Accreditation: The College of American Pathologists (CAP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CME Category 1: The College of American Pathologists designates this internet enduring material educational activity for a maximum of 1.5 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Payment Information
To pay with a check, print a copy of this page and send it with your check to the address below. You will be notified when your payment has been processed and you have been registered into the activity.

College of American Pathologists
CAP Learning
325 Waukegan Road
Northfield, IL 60093-2750

Refund Policy
Refunds will be handled on an exception basis. Please submit your request to the CAP in writing via email at [email protected] or fax at 847-832-8006.

Technical Requirements
Pop-up blockers must be turned off.

The CAP recognizes that some Veteran’s Administration, US Government, and military participants may have difficulty accessing the online activity. If you experience difficulty or have any questions, please contact a representative of the Customer Contact Center at 800-323-4040 option 1 or [email protected].

Availability
This activity and evaluation are available March 17, 2025 - March 16, 2028, at 11:59 PM (CT). Upon completion of the activity your credit will be awarded. Your certificate may be downloaded from your Transcript.

CC: MOLTECH03W.2025

Key Words: BrowseAP