Pricing: Member: $60.00 NonMember: $78.00 Junior Member: $15.00

To register for this activity, you must either pay by credit card or have ordered this product in advance. Click the Register tab then click the Enroll button, you will be prompted for validation or processed for payment.

To enroll in the series with one easy payment, or to enroll multiple participants from the same institution, call 800-323-4040 option 1. This option is only available until December 31, 2026, after this date this activity is only accessible by an online credit card payment.

Intended Audience
This clinical pathology activity is intended for pathologists.

Description
Discrepancies in serologic RhD testing can present diagnostic and therapeutic conundrums for clinicians. Discover which RhD variants can place patients at risk for developing anti-D upon exposure to the conventional D antigen through pregnancy or transfusion. Learn how molecular testing can be used to identify these at-risk patients.

Objectives
After completing this activity, you should be able to:

1. Describe the algorithmic approach to a pregnant patient with an indeterminate RhD type by serology.
2. Differentiate between transfusion management of patients with weak D variants compared to patients with partial D variants.
3. Explain why an individual can have discrepant RhD testing as a patient versus as a blood donor.
4. Identify the specimen requirements, utility, and limitations of molecular testing for RhD variants.

Authors/Faculty
Kerry Lynne O’Brien, MD, FCAP

Related Link
Clinical Pathology Improvement Program

CME Information
Accreditation: The College of American Pathologists (CAP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CME Category 1: The College of American Pathologists designates this internet enduring material educational activity for a maximum of 1.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Payment Information
To pay with a check, print a copy of this page and send it with your check to the address below. You will be notified when your payment has been processed and you have been registered into the activity.

College of American Pathologists
CAP Learning
325 Waukegan Road
Northfield, IL 60093-2750

Refund Policy
Refunds will be handled on an exception basis. Please submit your request to the CAP in writing via email at [email protected] or fax at 847-832-8006.

Technical Requirements
Pop-up blockers must be turned off.

The CAP recognizes that some Veteran’s Administration, US Government, and military participants may have difficulty accessing the online activity. If you experience difficulty or have any questions, please contact a representative of the Customer Contact Center at 800-323-4040 option 1 or [email protected].

Availability
This activity and evaluation are available April 20, 2026 - April 19, 2029, at 11:59 PM (CT). Upon completion of the activity your credit will be awarded. Your certificate may be downloaded from your Transcript.

CC: CPIP0404W.2026

Key Words: BrowseCP, RHD Genotyping, Unresolved RhD Type, Rh Immune Globulin