Pricing: Member: $60.00 NonMember: $78.00 Junior Member: $15.00

To register for this activity, you must either pay by credit card or have ordered this product in advance. Click the Register tab then click the Enroll button, you will be prompted for validation or processed for payment.

To enroll in the series with one easy payment, or to enroll multiple participants from the same institution, call 800-323-4040 option 1. This option is only available until December 31, 2025, after this date this activity is only accessible by an online credit card payment.

Intended Audience
This clinical pathology activity is intended for pathologists.

Description
Hyperbilirubinemia occurs because of hemolysis, impaired conjugation, hepatocellular disease, or biliary obstruction. Distinguishing these conditions is aided through the measurements of total and conjugated bilirubin, urobilinogen, and hepatobiliary enzymes. These common tests provide an important window into hepatobiliary function that is necessary for the diagnosis and management of hepatobiliary disease. This activity will review proper interpretation of total bilirubin, conjugated bilirubin, urobilinogen, and the hepatobiliary enzymes that will assist the pathologist whether supervising a chemistry laboratory or serving as a surgical pathologist.

Objectives
After completing this activity, you should be able to:

1. Describe the normal physiology of bilirubin and urobilinogen (eg, production and excretion).
2. Compare and contrast the measurement of bilirubin and its fractions using the diazo reaction versus the dry-slide spectrophotometric measurement of unconjugated bilirubin (BU) and conjugated bilirubin (BC).
3. Interpret plasma bilirubin and urine urobilinogen measurements in differentiating conjugated versus unconjugated forms of hyperbilirubinemia.
4. Distinguish hepatocellular disease versus biliary tract obstruction through the measurement of the hepatobiliary enzymes ALT, AST, and ALP.

Authors/Faculty
William E. Winter, MD, FCAP

Related Link
Clinical Pathology Improvement Program

CME Information
Accreditation: The College of American Pathologists (CAP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CME Category 1: The College of American Pathologists designates this internet enduring material educational activity for a maximum of 1.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Payment Information
To pay with a check, print a copy of this page and send it with your check to the address below. You will be notified when your payment has been processed and you have been registered into the activity.

College of American Pathologists
CAP Learning
325 Waukegan Road
Northfield, IL 60093-2750

Refund Policy
Refunds will be handled on an exception basis. Please submit your request to the CAP in writing via email at [email protected] or fax at 847-832-8006.

Technical Requirements
Pop-up blockers must be turned off.

The CAP recognizes that some Veteran’s Administration, US Government, and military participants may have difficulty accessing the online activity. If you experience difficulty or have any questions, please contact a representative of the Customer Contact Center at 800-323-4040 option 1 or [email protected].

Availability
This activity and evaluation are available May 19, 2025 - May 18, 2028, at 11:59 PM (CT). Upon completion of the activity your credit will be awarded. Your certificate may be downloaded from your Transcript.

CC: CPIP0505W.2025

Key Words: BrowseCP