Pricing: Member: $50.00 NonMember: $65.00 Junior Member: $10.00

To register for this activity, you must either pay by credit card or have ordered this product in advance. Click the Register tab then click the Enroll button, you will be prompted for validation or processed for payment.

To enroll in the series with one easy payment, or to enroll multiple participants from the same institution, call 800-323-4040 option 1. This option is only available until December 31, 2023, after this date this activity is only accessible by an online credit card payment.

Intended Audience
This clinical pathology activity is intended for pathologists.

Description
Platelet refractoriness can be life threatening for thrombocytopenic patients. Narrowing the differential diagnosis for poor platelet transfusion response is critical to guide appropriate management and product selection. This can be accomplished by reviewing clinical history, physical examination, and laboratory findings to distinguish between nonimmune and immune/antibody mediated causes. This activity will help pathologists recognize platelet refractoriness and evaluate its cause to better help thrombocytopenic patients.

Objectives
After completing this activity, you should be able to:

1. Develop a differential diagnosis for poor response to platelet transfusion.
2. Distinguish between immune and nonimmune causes of platelet refractoriness.
3. Calculate corrected count increments (CCI).
4. Correlate the pattern of platelet count response to the pathophysiology of refractoriness.
5. Describe options for obtaining suitable platelets for patients with human leukocyte antigen (HLA) refractoriness.

Authors/Faculty
Melissa R. George, DO, FCAP
Sarah W. Kesterson, MD

Related Link
Clinical Pathology Improvement Program

CME Information
Accreditation: The College of American Pathologists (CAP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CME Category 1: The College of American Pathologists designates this internet enduring material educational activity for a maximum of 1.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Payment Information
To pay with a check, print a copy of this page and send it with your check to the address below. You will be notified when your payment has been processed and you have been registered into the activity.

College of American Pathologists
CAP Learning
325 Waukegan Road
Northfield, IL 60093-2750

Refund Policy
Refunds will be handled on an exception basis. Please submit your request to the CAP in writing via email at education@cap.org or fax at 847-832-8006.

Technical Requirements
Pop-up blockers must be turned off.

The CAP recognizes that some Veteran’s Administration, US Government, and military participants may have difficulty accessing the online activity. If you experience difficulty or have any questions, please contact a representative of the Customer Contact Center at 800-323-4040 option 1 or education@cap.org.

Availability
This activity and evaluation are available May 15, 2023 - May 14, 2026, at 11:59 PM (CT). Upon completion of the activity your credit will be awarded. Your certificate may be downloaded from your Transcript.

CC: CPIP0505W.2023

Key Words: Thrombocytopenia, Immune Platelet Destruction, Disseminated Intravascular Coagulation (DIC), BrowseCP