Pricing: Member: $50.00 NonMember: $65.00 Junior Member: $10.00

To register for this activity, you must either pay by credit card or have ordered this product in advance. Click the Register tab then click the Enroll button, you will be prompted for validation or processed for payment.

To enroll in the series with one easy payment, or to enroll multiple participants from the same institution, call 800-323-4040 option 1. This option is only available until December 31, 2022, after this date this activity is only accessible by an online credit card payment.

Intended Audience
This clinical pathology activity is intended for pathologists.

Description
Precision medicine in cancer increasingly relies on molecular analysis of solid tumor samples. The pathologist’s involvement in coordination and facilitation of patient samples for testing is critical. Preanalytical factors encompass all steps preceding molecular analysis from sample procurement to submission of tissue for testing and includes multiple considerations at each stage of handling. These factors play an important role in the overall quality of the molecular testing and are essential for the pathologist to recognize and optimize to obtain the highest quality results.

Objectives
After completing this activity, you should be able to:

1. Describe the impact of cold ischemic time, fixative time, fixative types, and processing conditions on nucleic acid recovery and downstream testing.
2. Identify ways to mitigate interferences and artifacts in molecular testing.
3. Recognize how tissue selection and macrodissection can impact molecular testing.
4. Select acceptable solid tumor samples for molecular testing in both routine and challenging cases.

Authors/Faculty
Sara L. Cook, MD, PhD, FCAP
Theresa Spivey, MD
Jennifer M. Yoest, MD, FCAP

Related Link
Clinical Pathology Improvement Program

CME Information
Accreditation: The College of American Pathologists (CAP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CME Category 1: The College of American Pathologists designates this internet enduring material educational activity for a maximum of 1.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Payment Information
To pay with a check, print a copy of this page and send it with your check to the address below. You will be notified when your payment has been processed and you have been registered into the activity.

College of American Pathologists
CAP Learning
325 Waukegan Road
Northfield, IL 60093-2750

Refund Policy
Refunds will be handled on an exception basis. Please submit your request to the CAP in writing via email at education@cap.org or fax at 847-832-8006.

Technical Requirements
Pop-up blockers must be turned off.

The CAP recognizes that some Veteran’s Administration, US Government, and military participants may have difficulty accessing the online activity. If you experience difficulty or have any questions, please contact a representative of the Customer Contact Center at 800-323-4040 option 1 or education@cap.org.

Availability
This activity and evaluation are available December 19, 2022 - December 18, 2025, at 11:59 PM (CT). Upon completion of the activity your credit will be awarded. Your certificate may be downloaded from your Transcript.

CC: CPIP1212W.2022

Key Words: Fixation Effects on Nucleic Acids, Decalcification Effects on Nucleic Acids, Tumor Percentage, BrowseCP