Pricing: Member: $40.00 NonMember: $52.00 Junior Member: $10.00

Intended Audience
This anatomic pathology activity is intended for pathologists who have various levels of experience in breast pathology and who want to further develop their skills in the use and interpretation of IHC markers for diagnosis.

Description
This activity focuses on the use of IHC in diagnostic breast pathology. Through a series of cases, learners will recognize pitfalls in the use of myoepithelial stains and E-cadherin, understand the IHC staining patterns of various papillary lesions, and review markers that aid in the work-up of an unknown primary tumor when breast carcinoma is a consideration.

This activity was originally presented at Pathology in the Park in 2022.

Objectives
After completing this activity, you should be able to:

1. Recognize the pitfalls in the use of myoepithelial markers related to specific breast proliferations such as sclerosing lesions and papillary lesions.
2. Know the sources of cross-reactivity (blood vessels, stroma) associated with certain myoepithelial markers.
3. Determine site of origin (mammary versus non-mammary) of a metastatic tumor using traditional (ER, CK7, CK20, mammaglobin, GCDFP-15) and newer (GATA3, SOX10) IHC stains.

Authors/Faculty
Timothy M. D'Alfonso, MD

CME Information
Accreditation: The College of American Pathologists (CAP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CME Category 1: The College of American Pathologists designates this internet enduring material educational activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Payment Information
To pay with a check, print a copy of this page and send it with your check to the address below. You will be notified when your payment has been processed and you have been registered into the activity.

College of American Pathologists
CAP Learning
325 Waukegan Road
Northfield, IL 60093-2750

Refund Policy
Refunds will be handled on an exception basis. Please submit your request to the CAP in writing via email at education@cap.org or fax at 847-832-8006.

Technical Requirements
Pop-up blockers must be turned off.

The CAP recognizes that some Veteran’s Administration, US Government, and military participants may have difficulty accessing the online activity. If you experience difficulty or have any questions, please contact a representative of the Customer Contact Center at 800-323-4040 option 1 or education@cap.org.

Availability
This activity and evaluation are available November 14, 2022 - November 13, 2025, at 11:59 PM (CT). Upon completion of the activity your credit will be awarded. Your certificate may be downloaded from your Transcript.

CC: BRSTIHC11W.2022

Key Words: Myoepithelium, Adenosis, BrowseAP